Recent Publications
A selection of our recent publications:
Safety and efficacy of the SNAP 12-hour acetylcysteine regimen for the treatment of paracetamol overdose. Pettie JM, Caparrotta TM, Hunter RW, Morrison EE, Wood DM, Dargan PI, Thanacoody RH, Thomas SHL, Elamin MEMO, Francis B, Webb DJ,Sandilands EA, Eddleston M, Dear JW. EClinicalMedicine 2019; 11: 11-17.
New drug controls and reduced hospital presentations due to novel psychoactive substances in Edinburgh. Pettie J, Burt A, Knipe DW, Torrance H, Dow M, Osinski K, Greig R, Sabatini D, Easterford K, Dear J, Eddleston M. Br J Clin Pharmacol 2018, 84: 2303-10.
Iron overdose epidemiology, clinical features and iron concentration-effect relationships: the UK experience 2008-2017. Bateman DN, Eagling V, Sandilands EA, Jackson G, Crawford C, Hawkins L, Cheung T, Cooper G, Bradberry SM, Thompson JP, Thomas SHL, Eddleston M. Clin Toxicol 2018; 56: 1098-106.
Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. Caparrotta TM, Antoine DJ, Dear JW. Eur J Clin Pharmacol 2018; 74: 147-60.
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ. Lancet Gastroenterol Hepatol 2018; 3: 104-113.
Hospital usage of TOXBASE in Great Britain: Temporal trends in accesses 2008 to 2015. Pyper K, Eddleston M, Bateman DN, Lupton D, Bradberry S, Sandilands E, Thomas S, Thompson JP, Robertson C. Hum Exp Toxicol 2018; 37: 1207-14.
Transformative biomarkers for drug-induced liver injury: are we there yet? Antoine DJ, Dear JW. Biomark Med 2017; 11: 103-6.
Should we treat very large paracetamol overdose differently? Bateman DN, Dear JW. Br J Clin Pharmacol 2017; 83: 1163-5.
Overdose in young children treated with anti-reflux medications: Poisons enquiry evidence of excess 10-fold dosing errors with ranitidine. Crawford C, Anderson M, Cooper G, Jackson G, Thompson J, Vale A, Thomas S, Eddleston M, Bateman DN. Hum Exp Toxicol 2017; 37: 343-9.
MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury. Vliegenthart ADB, Berends C, Potter CMJ, Kersaudy-Kerhoas M, Dear JW. Br J Clin Pharmacol 2017; 83: 2027-33.
